Intra Cytoplasmic Sperm Injection (ICSI)

At The British Clinic, access to the latest techniques in infertility management is provided in a friendly atmosphere. Questions and suggestions are always welcomed to improve the care. We pride ourselves on our personal approach to the problem of infertility. Our team is constantly updating knowledge on infertility management to provide the expected successful outcome. This is the reason for steady improvement in our success.

Our centre collaborates with other centres local, national and international.

Intracytoplasmic sperm injection, or ICSI, is a micromanipulation technique developed to help achieve fertilization for couples with severe male factor infertility. The procedure overcomes many of the barriers to fertilization and allows couples with the hope to obtain fertilized embryos  and achieving successful pregnancy.

Generally speaking, the situation where ICSI is considered absolutely necessary is in the case of male factor infertility with an abnormal semen analysis. Other reasons include previous poor fertilization with IVF, decreased number of eggs for fertilization, variable sperm counts, and unexplained infertility. Thus, many patients choose to undergo the ICSI procedure in order to maximize their success even when the procedure may not be clearly indicated.


How ICSI Works
The technique involves very precise maneuvers to pick up a single live sperm and inject it directly into the center of a human egg. The procedure requires that the female partner undergo ovarian stimulation with fertility medications so that several mature eggs develop. These eggs are then aspirated through the vagina, using vaginal ultrasound, and incubated under precise conditions in the embryology laboratory. The semen sample is prepared by centrifuging (spinning the sperm cells through a special medium). This solution separates live sperm from debris and most of the dead sperm. The embryologist picks up the single live sperm in a glass needle and injects it directly into the egg.


BENEFITS OF ICSI
ICSI is suitable for attempting to achieve fertilisation where the sperm of the male partner are unable of achieving acceptable fertilisation rates using routine IVF technique . ICSI has been shown to achieve fertilisation rates of about 70%. ("Normal" sperm will fertilise about 70% of mature eggs in normal IVF).

ICSI has resulted in pregnancy rates which are slightly higher than that of the routine IVF success rates. These rates depend to a large extent on:

  1. The age of the woman
  2. Her infertility status and cause
  3. Number of embryos replaced

Men whose sperm are unable to achieve adequate fertilisation rates in IVF now have the opportunity to father their own children with the use of ICSI, which would not have been possible any other way.

There is evidence that the incidence of abnormalities in foetuses and children resulting from ICSI procedures is no greater than in the normal population.

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